"When the Spirit of truth comes, He will guide you into all the truth" (John 16:13).
Yes, they will inevitably perish if they do not take care of themselves, if they do not awaken from their sleep, if they do not pray, if they do not change. Yes, prayer, prayer is the only and last means through which such Christians can get out of the darkness of ignorance. That is why a person perishes in the darkness of ignorance and delusion, because he does not listen, does not read, does not understand Christian, divine truths, does not pray to God.
Our soul lives and acts only by prayer, only during prayer is it illuminated with the light of truth. The more a person prays, the more lively and active the soul becomes. A soul without prayer is dead, and as such is not capable of anything spiritual, holy and true. Look at the people who are virtuous, see how much they pray. They spend all their time in prayer. That is why they are virtuous, because they do a lot of good, because they pray a lot; if they stop praying, they will cease to be virtuous and give up good deeds. Look also at all true believers; see how they often pray. They pray incessantly. Yes, that is why they believe firmly because they pray incessantly; with a weakening of zeal for prayer, faith itself will inevitably weaken in them. Faith and good deeds are the fruits of prayer. Thus, spiritual life and prayer are closely, inextricably linked.
He who lives a spiritual and pious life loves to pray and prays without fail. Just as bodily life is revealed and sustained by breathing - since he who ceases to breathe ceases to live - so by prayer is revealed and sustained a spiritual, pious life; he lives badly, viciously, who prays little and rarely.
Therefore, this is why some of the Christians do not believe rightly, do not have an accurate understanding of the most important and necessary Christian truths: because they do not pray to God. Therefore, they have no desire to learn divine truths; that is why it makes no sense to understand divine truths: one does not pray to God; their soul is dead, incapable of anything divine. The one who died cannot be cured, and the one who does not pray to God cannot be taught anything.
So, listeners, if there are such among you, then hurry to get out of the darkness of ignorance, pray to God, pray as often as possible. A desire to know divine truths will be born in you, and then you will be happy to listen and read about them, then you will clearly understand them and keep them in your memory for a long time. Turn your whole soul to God, and He will guide you into all truth, and He will give you an opportunity and show you the means to know the truth. God is the everlasting light and infinite love; He will not leave a pagan in the darkness of ignorance; He will lead the heretic out of the darkness of delusions; He will take the depraved one out of the abyss of sins; He will not allow anyone to remain in the darkness of ignorance and delusion, as long as one only prays to Him. Amen.