The current owners of the estate are the children of Tasos Panagiotopoulos, including the Professor of Medicine Panagiotis (Takis) Panagiotopoulos. The main buildings within the estate were built by the original owner in the 1920s. The largest of all is the Villa Panagiotopoulos, a masterpiece of Art Nouveau, now owned by Mrs. Ismini (Minni) Panagiotopoulos. There are also newer utility buildings behind the villa, which are not completely visible from the Salamis Coast, where the main entrance is located.
The church is identical to Church of Saint Nicholas of the Thon Estate in Athens, which was built in 1891 according to the plans of the same architect. The only significant difference between the two buildings is the external shape of the dome. The dome at Saint Nicholas of the Thon is made of ascending concentric circles of plinths, while the corresponding one at Saint Anastasios the Persian is made of colored mortar with protruding radial ends from the top to the sides.