
In 1353 he was made Patriarch of Constantinople; he stepped down after one year, but was recalled to the Patriarchal throne in 1364. He continued to be a zealous champion of undiluted Orthodoxy, writing treatises setting forth the theology of the Uncreated Energies of God and refuting the scholastic philosophy that was then infecting the Western church. Despite (or because of?) his uncompromising Orthodoxy, he always sought a true, rather than political, reconciliation with the West, and even worked to convene an Ecumenical Council to resolve the differences between the churches; this was rejected by Pope Urban V. In 1368 he led the synodal decision to proclaim St. Gregory Palamas a Saint and ordained the Second Sunday of Great Lent to be his feast. St. Philotheos composed the Church's services to St Gregory Palamas. This holy Patriarch was deposed in 1376 when the Emperor Andronicus IV came to the throne; he died in exile in 1379. His tomb at the Monastery of Akatalyptos Maria Diakonissa became a place of many miracles.
St. Philotheos is celebrated in the Orthodox Church on the Fifth Sunday of Great Lent and on October 11th. He is a Protector of Orthodoxy alongside Sts. Photios the Great, Mark Evgenikos, and Gregory Palamas.